Fig. 6
From: NKX6-1 mediates cancer stem-like properties and regulates sonic hedgehog signaling in leiomyosarcoma
NKX6-1 activation enhances chemosensitivity to an SHH inhibitor. Dose–response curves (a and b, left panel) and growth curves (b, middle and right panel) of LMS cells and NKX6-1-overexpressing vs. -knockdown cells treated for 96 h with SHH (RU-SKI 43) and NOTCH (DAPT) inhibitors. c Immunohistochemical analysis of GLI1 protein expression in LMS tissue from four patients. The scale bar represents 200 μm. d Kaplan–Meier analysis of overall survival stratified by HHAT expression in LMS patients from the TCGA dataset. e Kaplan–Meier analysis of overall survival stratified by combined NKX6-1 and HHAT expression in LMS patients from the TCGA dataset. *p < 0.05