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Fig. 6 | Journal of Biomedical Science

Fig. 6

From: Proteomics-based identification of TMED9 is linked to vascular invasion and poor prognoses in patients with hepatocellular carcinoma

Fig. 6

Prediction of potential interactions between cargo-transport proteins with TMED9 and their prognostic values in hepatocellular carcinoma (HCC). a TMED9 protein–protein interaction network of 10 differentially expressed genes from the STRING database. b Gene ontology analysis revealed that TMED9 participates in endoplasmic reticular (ER)-Golgi cargo trafficking. c Correlation analysis of The Cancer Genome Atlas (TCGA) Liver Hepatocellular Carcinoma database using the cBioPortal revealed positive correlations between TMED9 and mRNA levels of STX5, TMED3, and SURF4. d Effects of TMED9 and TMED3 mRNA levels on patient overall survival from the TCGA cohort. e, f Mahlavu (e) and HCC36 (f) cells respectively expressed shTMED9 and HA-TMED9 as indicated. Cell lysates and conditioned media were harvested to determine the expression of β-catenin and GLI1, phosphorylation of ERK and STAT3, and secretion of TGF-α in both cells by Western blotting and dot blot analyses

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Journal of Biomedical Science

ISSN: 1423-0127