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Table 5 Cox univariate and multivariate regression analysis of prognostic factors and TMED9 expression for disease-free survival (DFS) in 182 hepatocellular carcinoma (HCC) patients

From: Proteomics-based identification of TMED9 is linked to vascular invasion and poor prognoses in patients with hepatocellular carcinoma

Variables

Comparison

HR (95% CI)

P value

Cox Univariate Analysis (DFS)

 Age

 < 61 years; ≥ 61 years

0.814 (0.583–1.138)

0.229

 Gender

Female; male

0.866 (0.549–1.366)

0.536

 Stage

I; II; III

1.248 (0.977–1.594)

0.076

 AFP

 < 400 ng/mL; ≥ 400 ng/mL

1.159 (0.753–1.782)

0.503

 HBV

Negative; positive

1.262 (0.897–1.777)

0.182

 HCV

Negative; positive

1.090 (0.753–1.577)

0.649

 Tumor size

 ≤ 5 cm; > 5 cm

1.371 (0.979–1.920)

0.066

 Cut margin

 < 1 cm; > 1 cm

0.686 (0.481–0.979)

0.038*

 PVI

No; yes

3.662 (2.043–6.567)

0.000***

 HVI

No; yes

11.333 (5.191–24.138)

0.000***

 TMED9

Low; high

1.506 (1.076–2.107)

0.017*

Cox Multivariate Analysis (DFS)

 Cut margin

 ≤ 1 cm; > 1 cm

0.770 (0.525–1.129)

0.181

 PVI

No; yes

2.438 (1.268–4.688)

0.008**

 HVI

No; yes

8.273 (3.531–19.381)

 < 0.001***

 TMED9

Low; high

1.173 (0.807–1.703)

0.403

  1. All terms are defined in the legend to Table 4