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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Applications of brain organoids in neurodevelopment and neurological diseases

Fig. 1

Schematic of the generation and applications of brain organoids. ESCs from human embryonic tissues and PSCs from adult tissues first divide and aggregate into EBs, are placed in neural induction media to induce neuroectoderm formation, and are subsequently transferred into Matrigel droplets to expand the neuroepithelium. The cultures during this period are early brain organoids. Last, these tissues will be cultured in the spinning bioreactor to enhance nutrient absorption for further maturation and preservation. Brian organoids can be used to recapitulate the process of human brain development and to investigate the factors affecting neurogenesis. Brain organoid technology can be exploited to model a variety of human neurological disorders, such as tumors and microcephaly, to explore the pathogenic mechanism and identify an effective treatment for patients

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