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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: RhoA: a dubious molecule in cardiac pathophysiology

Fig. 2

Posttranslational modifications of RhoA. Substrate is GGPP or FPP from the cholesterol generating mevalonate pathway. The first step is the prenylation by an isoprenyl-transferase (GGTase1) or the farnesyl-transferase (FTase), i.e. the adding of a 20GG- or 15F-moiety to the cysteine of the CaaX motif at the C-terminus of the RhoA-polypeptide. The second step is the proteolytic cleavage of the aaX-moieties of that motif by the protease Rce1. The last step is the methylation of the remaining cysteine by the ICMT

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