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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: RhoA: a dubious molecule in cardiac pathophysiology

Fig. 4

Activation of RhoA by ligand-induced GPCR activation and Gα-GEF interaction. A link between RhoA-activation and extracellular stimuli is the binding of ligands to GPCRs which activate Gαq/11 or Gα12/13 that in turn act as activators for RhoGEFs. In addition, biomechanical stress is also linked to Gαq/11, GEF and RhoA-activation

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