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Table 1 GEFs, GAPs, GDIs, and GDFs of RhoA

From: RhoA: a dubious molecule in cardiac pathophysiology

Group Regulator name in human (mouse) Interaction with SMGS Domains Receptor activation References
GEFs Dbl Rho/Rac/Cdc42 DH/PH (Gαq/11) [56, 136, 174]
Dbs Rho, Cdc42 DH/PH (Gαq/11) [136, 171]
LARG-RhoGEF (ARHGEF12) Rho DH/PH, PDZ Gα12/13 [3, 159]
Lbc (AKAP/ARHGEF13) Rho DH/PH Gα12/13 [3, 183]
Lfc (ARHGEF2/GEF-H1) Rho DH/PH Gα12/13 [50, 107]
p63RhoGEF, *GEFT Rho DH/PH Gαq/11 [100, 136]
p115RhoGEF (ARHGEF1/Lsc) Rho DH/PH, RH Gα12/13 [50, 57, 85]
PDZ-RhoGEF (ARHGEF11) Rho DH/PH, RH, PDZ Gα12/13 [3, 46]
Vav1 Rho/Rac/Cdc42 DH/PH, SH2 Src [28]
Vav2 Rho DH/PH, SH2 Src [145]
Group Regulator (name) Interaction with SmGs Model Reference
GAPs Graf Rho, Cdc42 Chicken embryo (CE) cells [62]
Dlc1 Rho/Rac/Cdc42 Tumor cells (liver, HeLa) [177]
Myr5 Rho, Cdc42 Isolated GTPases [129]
RA-RhoGAP Rho Smooth muscle [184]
ARAP3 Rho, Arf Smooth muscle [184]
p50RhoGAP Rho, Rac, Cdc42 Kidney cells (HEK), fibroblasts (COS-7) [11, 87]
p190RhoGAP Rho Rac, Cdc42 Tumor cells (HeLa), fibroblasts (COS-7), neurons [7, 59, 132]
Group Regulator (name) Interaction with SmGs Model Reference
GDIs RhoGDI1 (RhoGDIα) Rho/Rac/Cdc42 Neurons [166]
*RhoGDI2 (RhoGDIβ/D4/ Ly-GDI) Rho/Rac/Cdc42 Lymphocytes [92, 144]
*RhoGDI3 (RhoGDIγ) RhoB and RhoG (not RhoA and RhoC) Tumor cells (HeLa) [180]
Group Regulator (name) Interaction with GDIs Model Reference
GDFs ERM RhoGDIα Fibroblasts (COS-7) [160]
p75NTR RhoGDI Neuroblasts (PC12) [175]
IΚΚγ/NEMO RhoGDI HEK cells (293 T) [80]
  1. Listed are the GEFs, GAPs, GDIs and GDFs which have been shown to interact with RhoA. For the GEFs the SmG-(sub-) family with which members they interact besides RhoA is listed, as well as the conserved domains which are responsible for the interaction with the SmG and the mechanism of activation. For the GAPs, GDIs and GDFs also the interaction partners and the cell model in which the activity on RhoA has been shown are listed. (* = isoform)