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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: Notch-ing up knowledge on molecular mechanisms of skin fibrosis: focus on the multifaceted Notch signalling pathway

Fig. 3

NOTCH1 activation in fibroproliferative skin diseases. Immunohistochemical staining pattern showing the expression levels of the cleaved, biologically active NOTCH1 protein (NICD, Notch intracellular domain) in skin biopsies from patients affected with four different fibroproliferative diseases and normal controls. In general, NICD is constitutively expressed in keratinocytes, endothelial cells and immune cells of patients affected with the various fibroproliferative disorders and healthy biopsies, with no significant variation among them. As for NICD expression in fibroblasts, it was generally low in morphea and barely detected in healthy controls. On the other hand, Notch pathway is activated in fibroblasts from keloids, hypertrophic scars and dermatofibromas. Figure adapted from [149]

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