Table 1 Genome-wide association study participant characteristics. Mean ± standard deviation

Participants

225

206

76

507

Sex (male/female)

187/38

156/50

42/34

385/122

Age (years)

53.4 ± 17.4

61.9 ± 12.2

46.6 ± 20.1

55.9 ± 16.9

Baseline relative V̇O_2peak (mL/kg/min)

32.1 ± 11.5

27.6 ± 8.1

30.4 ± 13.7

30.1 ± 10.8

Relative V̇O_2peak response (mL/kg/min)

3.4 ± 4.1

Range: − 6.5 to 18.4

2.9 ± 3.6

Range: − 7.4 to 15.3

1.9 ± 2.8

Range: − 4.6 to 8.8

*3.0 ± 3.8

Range: − 7.4 to 18.4

Number of ‘likely non responders’ (> 1 TEM below + MCID to < 1 TEM below the –MCID)

86 (38%)

V̇O_2peak response = − 0.6 ± 1.9 (mL/kg/min)

PPS: 2.7 ± 2.2

82 (40%)

V̇O_2peak response = 

− 0.5 ± 1.9 (mL/kg/min)

PPS: 2.5 ± 2.2

42 (55%)

V̇O_2peak response = − 0.1 ± 1.5 (mL/kg/min)

PPS: 2.4 ± 2.6

*210 (41.4%)

V̇O_2peak response = − 0.43 ± 1.9 (mL/kg/min)

PPS: 2.5 ± 2.3

Number of ‘Likely responders’ (> 1 TEM above the + MCID)

67 (30%)

V̇O_2peak response = 8.4 ± 2.8 (mL/kg/min)

PPS: 6.8 ± 3.7

43 (21%)

V̇O_2peak response = 8.0 ± 2.1 (mL/kg/min)

PPS: 6.3 ± 3.1

12 (16%)

V̇O_2peak response = 6.4 ± 0.9 (mL/kg/min)

PPS: 4.8 ± 2.3

**122 (24.1%)

V̇O_2peak response = 8.1 ± 2.4 (mL/kg/min)

PPS: 6.4 ± 2.7

Number of ‘uncertain’ responders (< 1 TEM above to < 1 TEM below + MCID)

72 (32%)

V̇O_2peak response = 3.6 ± 1.0 (mL/kg/min)

PPS: 3.5 ± 2.6

82 (39%)

V̇O_2peak response = 3.5 ± 3.6 (mL/kg/min)

PPS: 3.4 ± 2.9

22 (29%)

V̇O_2peak response = 3.1 ± 1.0 (mL/kg/min)

PPS: 3.5 ± 0.9

175 (34.5%)

V̇O_2peak response = 3.5 ± 0.99 (mL/kg/min)

PPS: 3.5 ± 3.1