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Table 1 Genome-wide association study participant characteristics. Mean ± standard deviation

From: Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study

  High-volume HIIT MICT Low-volume HIIT/SIT All
Participants 225 206 76 507
Sex (male/female) 187/38 156/50 42/34 385/122
Age (years) 53.4 ± 17.4 61.9 ± 12.2 46.6 ± 20.1 55.9 ± 16.9
Baseline relative V̇O2peak (mL/kg/min) 32.1 ± 11.5 27.6 ± 8.1 30.4 ± 13.7 30.1 ± 10.8
Relative V̇O2peak response (mL/kg/min) 3.4 ± 4.1
Range: − 6.5 to 18.4
2.9 ± 3.6
Range: − 7.4 to 15.3
1.9 ± 2.8
Range: − 4.6 to 8.8
*3.0 ± 3.8
Range: − 7.4 to 18.4
Number of ‘likely non responders’ (> 1 TEM below + MCID to < 1 TEM below the –MCID) 86 (38%)
V̇O2peak response = − 0.6 ± 1.9 (mL/kg/min)
PPS: 2.7 ± 2.2
82 (40%)
V̇O2peak response = 
− 0.5 ± 1.9 (mL/kg/min)
PPS: 2.5 ± 2.2
42 (55%)
V̇O2peak response = − 0.1 ± 1.5 (mL/kg/min)
PPS: 2.4 ± 2.6
*210 (41.4%)
V̇O2peak response = − 0.43 ± 1.9 (mL/kg/min)
PPS: 2.5 ± 2.3
Number of ‘Likely responders’ (> 1 TEM above the + MCID) 67 (30%)
V̇O2peak response = 8.4 ± 2.8 (mL/kg/min)
PPS: 6.8 ± 3.7
43 (21%)
V̇O2peak response = 8.0 ± 2.1 (mL/kg/min)
PPS: 6.3 ± 3.1
12 (16%)
V̇O2peak response = 6.4 ± 0.9 (mL/kg/min)
PPS: 4.8 ± 2.3
**122 (24.1%)
V̇O2peak response = 8.1 ± 2.4 (mL/kg/min)
PPS: 6.4 ± 2.7
Number of ‘uncertain’ responders (< 1 TEM above to < 1 TEM below + MCID) 72 (32%)
V̇O2peak response = 3.6 ± 1.0 (mL/kg/min)
PPS: 3.5 ± 2.6
82 (39%)
V̇O2peak response = 3.5 ± 3.6 (mL/kg/min)
PPS: 3.4 ± 2.9
22 (29%)
V̇O2peak response = 3.1 ± 1.0 (mL/kg/min)
PPS: 3.5 ± 0.9
175 (34.5%)
V̇O2peak response = 3.5 ± 0.99 (mL/kg/min)
PPS: 3.5 ± 3.1
  1. TEMs were slightly different for each training intervention and have been outlined in Table 3
  2. Technical error of measurement (TEM) = multiplying mean V̇O2peak value by a previously published coefficient of variation for V̇O2peak of 5.6%, Minimal Clinically Important Difference (MCID) = 3.5 mL/kg/min, Polygenic Predictor Score (PPS). *Significant difference between high-volume HIIT & low-volume HIIT/SIT (P < 0.05),
  3. **Significant difference between high-volume HIIT, MICT & low-volume HIIT/SIT (P < 0.05)