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Table 4 Lead SNP at each locus showing a trend for association with V̇O2peak response

From: Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study

SNP CHR BP P-value BETA Closet Gene Effect allele Other allele MAF
rs73074755 2 210627971 2.75 × 10–7 1.17 UNC80
Unc-80 Homolog, NALCN Channel Complex Subunit
A G 0.34
rs16875411 5 5359876 1.22 × 10–6 − 1.56 ADAMTS16
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 16
A G 0.12
rs2236368 6 41309353 4.27 × 10–6 1.97 TFEB
Transcription Factor EB
A G 0.068
rs111346648 7 2322104 4.86 × 10–6 3.27 AMZ1
Archaelysin Family Metallopeptidase 1
G A 0.026
rs6959961 7 79297997 2.61 × 10–7 1.19 MAGI2
Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 2
T C 0.44
rs2657147 11 4573236 4.08 × 10–6 − 1.08 OR52M1
Olfactory Receptor Family 52 Subfamily M Member 1
G A 0.37
rs145056992 11 23069615 2.92 × 10–6 2.89 CCDC179
Coiled-Coil Domain Containing 179
G A 0.036
rs79687662 15 92921291 1.85 × 10–6 2.33 IQGAP1
IQ Motif Containing GTPase Activating Protein 1
C T 0.052
rs11647343 16 84454267 3.10 × 10–6 1.12 ATP2C2
ATPase Secretory Pathway Ca2 + Transporting 2
C A 0.32
rs11874598 18 11064859 4.02 × 10–6 1.02 PIEZO2
Piezo Type Mechanosensitive Ion Channel Component 2
C T 0.47
rs149323705 20 30964328 4.52 × 10–6 4.42 ASXL1
Additional Sex Combs Like 1, Transcriptional Regulator
T C 0.014
rs73193458 21 33375476 3.13 × 10–6 1.49 CLDN14
Claudin 14
A G 0.14
  1. Genome build GRCH37, chromosome (CHR), single nucleotide polymorphism (SNP), physical position (BP), odds ratio (OR), responder/non-responder allele (A1), minor allele frequency (MAF)