Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study

Table 4 Lead SNP at each locus showing a trend for association with V̇O2peak response

SNP	CHR	BP	P-value	BETA	Closet Gene	Effect allele	Other allele	MAF
rs73074755	2	210627971	2.75 × 10^–7	1.17	UNC80 Unc-80 Homolog, NALCN Channel Complex Subunit	A	G	0.34
rs16875411	5	5359876	1.22 × 10^–6	− 1.56	ADAMTS16 A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 16	A	G	0.12
rs2236368	6	41309353	4.27 × 10^–6	1.97	TFEB Transcription Factor EB	A	G	0.068
rs111346648	7	2322104	4.86 × 10^–6	3.27	AMZ1 Archaelysin Family Metallopeptidase 1	G	A	0.026
rs6959961	7	79297997	2.61 × 10^–7	1.19	MAGI2 Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 2	T	C	0.44
rs2657147	11	4573236	4.08 × 10^–6	− 1.08	OR52M1 Olfactory Receptor Family 52 Subfamily M Member 1	G	A	0.37
rs145056992	11	23069615	2.92 × 10^–6	2.89	CCDC179 Coiled-Coil Domain Containing 179	G	A	0.036
rs79687662	15	92921291	1.85 × 10^–6	2.33	IQGAP1 IQ Motif Containing GTPase Activating Protein 1	C	T	0.052
rs11647343	16	84454267	3.10 × 10^–6	1.12	ATP2C2 ATPase Secretory Pathway Ca2 + Transporting 2	C	A	0.32
rs11874598	18	11064859	4.02 × 10^–6	1.02	PIEZO2 Piezo Type Mechanosensitive Ion Channel Component 2	C	T	0.47
rs149323705	20	30964328	4.52 × 10^–6	4.42	ASXL1 Additional Sex Combs Like 1, Transcriptional Regulator	T	C	0.014
rs73193458	21	33375476	3.13 × 10^–6	1.49	CLDN14 Claudin 14	A	G	0.14

Genome build GRCH37, chromosome (CHR), single nucleotide polymorphism (SNP), physical position (BP), odds ratio (OR), responder/non-responder allele (A1), minor allele frequency (MAF)

ISSN: 1423-0127