Table 5 Gene interactions and common biological pathways and processes between this study and previous findings

Signaling events mediated by VEGFR1 and VEGFR2

2.31 × 10^–4

HIF1A, IQGAP1, NRP2, AKT1

Cell adhesion molecules (CAMs)

3.76 × 10^–3

CLDN14, NLGN1, ITGB8 CD6

E-cadherin signaling in the nascent adherens junction

1.05 × 10^–2

IQGAP1, AKT1

Ion transport

3.24 × 10^–6

KCNH8, ENPP3, GRIK4, NLGN1, PPARD, NR3C1, APOE, ACE, RYR2, ACSL1, PIEZO2, SHANK2, KCNQ5, NALCN, KCNF1, SLC22A3, ATP2C2, AKT1, PRKG1, GRIN3A, SLC45A1, KCNT1, UNC80

Growth

6.25 × 10^–6

HIF1A, NDN, PPARD, NR3C1, APOE, ACVR1C, TTN, IQGAP1, NRP2, MAGI2, SHANK2, RPTOR, CD44, AKT1, PRKG1, H19, CNTF

Developmental growth

7.08 × 10^–6

NDN, PPARD, NR3C1, APOE, ACVR1C, TTN, IQGAP1, NRP2, MAGI2, SHANK2, AKT1, PRKG1, H19, CNTF

Regulation of cell population proliferation

8.22 × 10^–6

HIF1A, ENPP3, NDN, BIRC7, PPARD, NR3C1, APOE, ACVR1C, ACE, NRP2, FABP6, PRDM1, GSTP1, MAGI2, CD6, RPTOR, CD44, PINX1, AKT1, PRKG1, H19, CNTF

Regulation of membrane potential

8.64 × 10^–6

KCNH8, GRIK4, NLGN1, RYR2, PIEZO2, SHANK2, NALCN, AKT1, GRIN3A, KCNT1, CNTF

Response to oxygen-containing compound

9.78 × 10^–6

HDAC9, ASXL1, HIF1A, HLCS, ID3, CAT, PPARD, NR3C1, APOE, ACVR1C, ACE, ADCY5, RYR2, IQGAP1, PRDM1, ACSL1, GSTP1, CD6, RPTOR, AKT1, GRIN3A

cation transmembrane transport

1.53 × 10^–5

KCNH8, GRIK4, NLGN1, RYR2, PIEZO2, SHANK2, KCNQ5, NALCN, KCNF1, SLC22A3, ATP2C2, PRKG1, GRIN3A, SLC45A1, KCNT1, UNC80

Cation transport

1.63 × 10^–5

KCNH8, GRIK4, NLGN1, ACE, RYR2, PIEZO2, SHANK2, KCNQ5, NALCN, KCNF1, SLC22A3, ATP2C2, AKT1, PRKG1, GRIN3A, SLC45A1, KCNT1, UNC80

Neurogenesis

1.85 × 10^–5

HDAC9, HIF1A, ID3, NDN, NLGN1, NR3C1, APOE, IGQAP1, NRP2, PRDM1, YTHDF1, MAGI2, SHANK2, DBX1, CD44, AKT1, PRKG1, GRIN3A, CNTF, ACE, GSTP1

Neuron differentiation

1.93 × 10^–5

HDAC9, HIF1A, ID3, NDN, NLGN1, NR3C1, APOE, IGQAP1, NRP2, PRDM1, YTHDF1, MAGI2, SHANK2, DBX1, CD44, AKT1, PRKG1, GRIN3A, CNTF