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Table 5 Gene interactions and common biological pathways and processes between this study and previous findings

From: Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study

Biological pathways P-value Genes from input
Signaling events mediated by VEGFR1 and VEGFR2 2.31 × 10–4 HIF1A, IQGAP1, NRP2, AKT1
Cell adhesion molecules (CAMs) 3.76 × 10–3 CLDN14, NLGN1, ITGB8 CD6
E-cadherin signaling in the nascent adherens junction 1.05 × 10–2 IQGAP1, AKT1
Top 10 biological processes P-value Genes from input
Ion transport 3.24 × 10–6 KCNH8, ENPP3, GRIK4, NLGN1, PPARD, NR3C1, APOE, ACE, RYR2, ACSL1, PIEZO2, SHANK2, KCNQ5, NALCN, KCNF1, SLC22A3, ATP2C2, AKT1, PRKG1, GRIN3A, SLC45A1, KCNT1, UNC80
Growth 6.25 × 10–6 HIF1A, NDN, PPARD, NR3C1, APOE, ACVR1C, TTN, IQGAP1, NRP2, MAGI2, SHANK2, RPTOR, CD44, AKT1, PRKG1, H19, CNTF
Developmental growth 7.08 × 10–6 NDN, PPARD, NR3C1, APOE, ACVR1C, TTN, IQGAP1, NRP2, MAGI2, SHANK2, AKT1, PRKG1, H19, CNTF
Regulation of cell population proliferation 8.22 × 10–6 HIF1A, ENPP3, NDN, BIRC7, PPARD, NR3C1, APOE, ACVR1C, ACE, NRP2, FABP6, PRDM1, GSTP1, MAGI2, CD6, RPTOR, CD44, PINX1, AKT1, PRKG1, H19, CNTF
Regulation of membrane potential 8.64 × 10–6 KCNH8, GRIK4, NLGN1, RYR2, PIEZO2, SHANK2, NALCN, AKT1, GRIN3A, KCNT1, CNTF
Response to oxygen-containing compound 9.78 × 10–6 HDAC9, ASXL1, HIF1A, HLCS, ID3, CAT, PPARD, NR3C1, APOE, ACVR1C, ACE, ADCY5, RYR2, IQGAP1, PRDM1, ACSL1, GSTP1, CD6, RPTOR, AKT1, GRIN3A
cation transmembrane transport 1.53 × 10–5 KCNH8, GRIK4, NLGN1, RYR2, PIEZO2, SHANK2, KCNQ5, NALCN, KCNF1, SLC22A3, ATP2C2, PRKG1, GRIN3A, SLC45A1, KCNT1, UNC80
Cation transport 1.63 × 10–5 KCNH8, GRIK4, NLGN1, ACE, RYR2, PIEZO2, SHANK2, KCNQ5, NALCN, KCNF1, SLC22A3, ATP2C2, AKT1, PRKG1, GRIN3A, SLC45A1, KCNT1, UNC80
Neurogenesis 1.85 × 10–5 HDAC9, HIF1A, ID3, NDN, NLGN1, NR3C1, APOE, IGQAP1, NRP2, PRDM1, YTHDF1, MAGI2, SHANK2, DBX1, CD44, AKT1, PRKG1, GRIN3A, CNTF, ACE, GSTP1
Neuron differentiation 1.93 × 10–5 HDAC9, HIF1A, ID3, NDN, NLGN1, NR3C1, APOE, IGQAP1, NRP2, PRDM1, YTHDF1, MAGI2, SHANK2, DBX1, CD44, AKT1, PRKG1, GRIN3A, CNTF
  1. Bolded genes from input from the Predict-HIIT cohort. All other genes from previous research