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Table 2 List of clinical trials of MSC-derived exosomes-based therapies

From: New therapeutic approaches of mesenchymal stem cells-derived exosomes

NCT number Study title Study start Condition Intervention Phase Status
NCT04602104 A Clinical Study of Mesenchymal Stem Cell Exosomes Nebulizer for the Treatment of ARDS October 2020 Acute Respiratory Distress Syndrome Allogenic human
MSC-Exos
Phase 1
Phase 2
Not yet recruiting
NCT04602442 Safety and Efficiency of Method of Exosome Inhalation in COVID-19 Associated Pneumonia (COVID-19EXO2) October 1, 2020 Covid19;
SARS-CoV-2 PNEUMONIA
MSC-Exos Phase 2 Enrolling by invitation
NCT04173650 MSC EVs in Dystrophic Epidermolysis Bullosa September 2020 Dystrophic Epidermolysis Bullosa AGLE 102 Phase 1
Phase 2
Not yet recruiting
NCT04356300 Exosome of Mesenchymal Stem Cells for Multiple Organ Dysfuntion Syndrome After Surgical Repaire of Acute Type A Aortic Dissection September 1, 2020 Multiple Organ Failure UC MSC-Exos Not Applicable Not yet recruiting
NCT04491240 Evaluation of Safety and Efficiency of Method of Exosome Inhalation in SARS-CoV-2 Associated Pneumonia July 20, 2020 Covid19;
SARS-CoV-2 PNEUMONIA
MSC-Exos Phase 1
Phase 2
Completed
has results
NCT04544215 A Clinical Study of Mesenchymal Progenitor Cell Exosomes Nebulizer for the Treatment of Pulmonary Infection July 1, 2020 Drug-resistant Human AD
MS progenitor cell-Exos
Phase 1
Phase 2
Recruiting
NCT04388982 the Safety and the Efficacy Evaluation of Allogenic Adipose MSC-Exos in Patients With Alzheimer's Disease July 1, 2020 Alzheimer´s Disease allogenic
AD MSC-Exos
Phase 1
Phase 2
Recruiting
NCT03608631 iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation March 2020 Pancreatic cancer with KrasG12D mutation;
Metastatic Pancreatic Adenocarcinoma;
Pancreatic Ductal Adenocarcinoma;
Stage IV Pancreatic Cancer AJCC v8
MSC-Exos with KRAS G12D siRNA Phase 1 Not yet recruiting
NCT04313647 A Tolerance Clinical Study on Aerosol Inhalation of Mesenchymal Stem Cells Exosomes In Healthy Volunteers March 16, 2020 Healthy Allogenic
AD MSC-Exos
Phase 1 Recruiting
NCT04213248 Effect of UMSCs Derived Exosomes on Dry Eye in Patients With cGVHD February 18, 2020 Dry Eye UC MSC-Exos Phase 1
Phase 2
Recruiting
NCT04276987 A Pilot Clinical Study on Inhalation of Mesenchymal Stem Cells Exosomes Treating Severe Novel Coronavirus Pneumonia February 15, 2020 Coronavirus Allogenic
AD MSC-Exos
Phase 1 Completed
NCT03384433 Allogenic Mesenchymal Stem Cell Derived Exosome in Patients With Acute Ischemic Stroke April 17, 2019 Cerebrovascular Disorders Allogenic
MSC-Exos enriched by miR-124
Phase 1
Phase 2
Recruiting
NCT03437759 MSC-Exos Promote Healing of MHs March 1, 2017 Macular Holes MSC-Exos Early Phase 1 Recruiting
NCT03562715 microRNAs Role in Pre-eclampsia Diagnosis November 28, 2016 Pre-eclampsia    Completed
NCT02138331 Effect of Microvesicles and Exosomes Therapy on β-cell Mass in Type I Diabetes Mellitus (T1DM) April 2014 Diabetes Mellitus Type 1 UC blood MSC-Exos Phase 2
Phase 3
Unknown
  1. NCT number, ClinicalTrials.gov identifier; MSC-Exos, mesenchymal stem cells-derived exosomes