Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases

Table 1 Targets of LSD1 and their effect on gene expression

Targets	Residue	Functions	Effect	References
Histone H3	K4me2	Repression with CoREST, CtBP and NuRD	Gene repression	[6,7,8]
Histone H3	K9me2	Derepression of AR target genes with FOXA1	Gene activation	[10, 11]
Histone H4	K20me1	Regulation of memory formation (LSD1n*)	Gene activation	[19]
DNMT1	K1096	Maintenance of global DNA methylation through stabilization of DNMT1	Gene activation	[8]
FOXA1	K270	Derepression of AR target genes through stabilization of FOXA1	Gene activation	[11]
HIF-1α	K32	Regulation of tumor angiogenesis through stabilization of HIF-1α	Gene activation	[14]
p65	K314/315	Regulation of inflammatory response through stabilization of p65	Gene activation	[15]
AGO2	K726	Inhibition of anti-tumor immunity through stabilization of AGO2	Gene repression	[16]
SOX2	K42/117	Maintenance of pluripotency through stabilization of SOX2	Gene activation	[17]

^* neuron-specific isoform of LSD1
Listed are the target substrates of LSD1 and the cellular functions and effects of gene expression

ISSN: 1423-0127