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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Multiscale X-ray phase contrast imaging of human cartilage for investigating osteoarthritis formation

Fig. 2

X-PCI-CT images of a healthy (A) and moderately degenerated (B) cartilage sample, respectively. Images were acquired using X-rays of 60 keV and a voxel size of 6.1 × 6.1 × 6.1 µm3 at the ID17 beamline. A The three cartilage layers are visible and intact (superficial, middle and deep layer); B The superficial layer and the middle layer show deep defects and fissures with disturbances of the matrix architecture (red arrows), while the deep layer is still preserved. The chondrocytes in the degenerated sample (B) show changes in their morphology throughout the superficial layer with loss of their flattened shape in the superficial layer as well as enlargement and initial clustering in the middle layer

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