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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Identification of COVID-19 B-cell epitopes with phage-displayed peptide library

Fig. 4

Location of VGG residues in SARS-CoV-2 spike glycoprotein. a Conserved VGG residues in the SARS-CoV-2 spike protein are shown as spheres in the prefusion conformation. b VGG residues in SARS-CoV-2 spike RBD are colored pink. ACE2 receptor is shown as a ribbon structure and colored green, while SARS-CoV-2-RBD is shown in the surface representation and colored cyan. RBD residues involved in receptor interaction [18] are colored red, and the ACE2 binding interface is marked by a red dashed outline. c Details of the polar contacts between SARS-CoV-2-RBD and ACE2 are indicated. Polar interactions are denoted as red dashed lines. Side chains of residues are shown as sticks (left panel). The position of VGG residues corresponds to SARS-CoV RBD serine (S), threonine (T) and glycine (G) (right panel). d Comparison of SARS-CoV and SARS-CoV-2 RBD sequence. The reported epitope residues of CR3022, m396 and 80R SARS-CoV neutralizing antibodies are denoted by blue lines, asterisks and purple points, respectively [18, 24]. VGG conserved residues derived from COVID-19 sera/phage-displayed peptide library biopanning are colored yellow

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