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Table 2 US contrast agents with clinical approval

From: The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication

Contrast agent Shell content Diameter range (µm) Type of utilized gas Creator Place approved
Definity® [268] Octafluoropropane (C3F8) 1.1–3.3 Lipid Lantheus Medical
Canada and US
SonoVue® [269] Sulfur Hexafluoride (SF6) 2.5 Lipid Bracco Int Europe
Optison™ [268] Octafluoropropane (C3F8) 2.2–4.5 Albumin GE Healthcare US
Sonazoid® [270] Perfluorobutane (C4F10) 1.9–2.4 Lipid Daiichi
Pharmaceutical Co
BR-55 [271] Perfluorobutane (C4F10) 1.5 Phospholipid/lipo-peptide BRACCO Clinical trials in Europe
BR-14 [272] Perfluorobutane (C4F10) 2.0–2.5 Phospholipid BRACCO Clinical trials in Europe