Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy

Table 3 miRNA regulation in the glycan precursor synthesis

microRNA	Gene target	Function role of gene target in glycosylation	Regulatory effect in tumor	References
miR-1291	SLC2A1	Glucose transporter	Tumor Suppressive	[99]
miR-30c-2-3p	SLC2A1	Glucose transporter	Unknown	[100]
miR‐195‐5p	SLC2A3	Glucose transporter	Tumor Suppressive	[101]
miR-106a	SLC2A3	Glucose transporter	Tumor Suppressive	[102]
miR-129-5p	SLC2A3	Glucose transporter	Tumor Suppressive	[103]
miR-223	SLC2A4	Glucose transporter	Unknown	[104]
miR-133	SLC2A4	Glucose transporter	Unknown	[105]
miR-22	SLC35B2	Nucleotide Sugar Transport	Tumor Suppressive	[106]
miR-1764, miR-1700	SLC35B4	Nucleotide Sugar Transport	Unknown	[107]
miR-369-3p	SLC35F5	Nucleotide Sugar Transport	Tumor Suppressive	[108]
miR-32	SLC45A3	Glucose transporter	Unknown	[109]
miR-139-5p	HK1	Nucleotide Sugar Metabolism	Tumor Suppressive	[37]
miR-143	HK2	Nucleotide Sugar Metabolism	Unknown	[38]
miR-34a	GPI	Nucleotide Sugar Metabolism	Unknown	[40]
miR‑224‑5p	UAP1	Nucleotide Sugar Metabolism	Tumor Suppressive	[41]
miR‑451a	PMM2	Nucleotide Sugar Metabolism	Tumor Suppressive	[110]
miR‑125a-5p, miR-125b	TSTA3	Nucleotide Sugar Metabolism	Tumor Suppressive	[111]
miR-29a-3p, miR-29b-3p	CMAHP	Nucleotide Sugar Metabolism	Tumor Suppressive	[112]

ISSN: 1423-0127