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Fig. 9 | Journal of Biomedical Science

Fig. 9

From: RETRACTED ARTICLE: Downregulating lncRNA NEAT1 induces proliferation and represses apoptosis of ovarian granulosa cells in polycystic ovary syndrome via microRNA-381/IGF1 axis

Fig. 9

Overexpression of IGF1 impairs the biological activity of ovarian granulosa cells from PCOS rats induced by up-regulated miR-381. A Overexpression of IGF1 in ovarian granulosa cells from PCOS rats; B Difference in cell viability after transfection of ovarian granulosa cells from PCOS rats by CCK-8 assay; C, D Colony formation ability of ovarian granulosa cells from PCOS rats detected by colony formation assay; E PCNA and cyclin D1 mRNA expression in ovarian granulosa cells from PCOS rats by RT-qPCR; F, G Apoptosis of ovarian granulosa cells from PCOS rats after transfection by flow cytometry; H Caspase-3, Bax and Bcl-2 mRNA expression in ovarian granulosa cells from PCOS rats after transfection by RT-qPCR; N = 3. The data are all measurement data, expressed as mean ± standard deviation, *P < 0.05 vs. the pc-CON + mimic NC group; #P < 0.05 vs. the miR-381 mimic + pc-CON group, and one-way ANOVA and Tukey’s post hoc test was used for statistical analysis

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Journal of Biomedical Science

ISSN: 1423-0127