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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: MicroRNA-138-1-3p sensitizes sorafenib to hepatocellular carcinoma by targeting PAK5 mediated β-catenin/ABCB1 signaling pathway

Fig. 4

PAK5 attenuated cell apoptosis induced by sorafenib in HCC in vitro. A Western Blot was conducted to determine the transfection efficiency of PAK5/Vector, PAK5/WT, PAK5/S573N (constitutively active) and PAK5/K478M plasmids (constitutively inactive) in Hep3B and HepG2 cells. B and C The cell viability and flow cytometric analysis were used to assess the influence of PAK5 overexpression on cell viability and apoptosis in Hep3B and HepG2 cells. D Western Blot was conducted to determine the transfection efficiency of PAK5-siRNA. E and F The cell viability and flow cytometric analysis were used to assess the influence of PAK5 knockdown on cell viability and apoptosis in Hep3B-SR and HepG2-SR cells

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