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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: PSPC1 is a new contextual determinant of aberrant subcellular translocation of oncogenes in tumor progression

Fig. 3

TGIF1 is the contextual determinant of PML nucleocytoplasmic shuttling. (1) PML delocalization was initiated by escape of nuclear interaction with TGF-β Induced Factor Homeobox 1 (TGIF1) to prevent cPML translocation to the cytoplasm. (2) Cytoplasmic promyelocytic leukemia (cPML) appears to preferentially interact with phosphorylated Smad2/3 and acts as an essential activator of TGF-β signaling (3) Activation of the canonical TGF-β signaling pathway

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Journal of Biomedical Science

ISSN: 1423-0127