Fig. 6

EBP50 is a contextual determinant of EBP50 and β-catenin nucleocytoplasmic shuttling. (1) EBP50 interacts with the PTEN tumor suppressor to attenuate PDGF receptor signaling. (2) During tumor progression, EBP50 translocates to the nucleus to stabilize β-catenin/TCF-1 or dnTCF-1 for activation of Wnt oncogenic signaling