Fig. 1
From: The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease
mHTT leads to cellular dysfunctions and clinical symptoms in HD patients. mHTT is transcribed from mHTT gene with more than 36 CAG repeats, and then forms aggregates to cause cellular dysfunctions, such as in protein degradation systems and mitochondria, finally leading to neurodegenerations. Due to neurodegenerations, HD patients suffer clinical symptoms, including motor and cognitive deficits