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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent

Fig. 5

Time course of antagonist effects of compound 29 (0.1 mg/kg, IP), administered at different pretreatment (PT) before oxycodone (5.6 mg/kg), in the thermal antinociception assay (n = 7–8). X-axis: PT time for 29 before oxycodone injection. Y-axis: %Maximum possible effect (%MPE). Data are shown at the 15-min timepoint after oxycodone (i.e., its peak effect). Stars represent significance of post-hoc Sidak tests

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