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Table 2 Schild analysis and Ke values of antagonism of test compounds against fentanyl to MORs by cAMP functional assay

From: Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent

Cmpd

Slope ± SEM

pA2 ± SEM

Ke (nM) ± SEM

4b

1.12 ± 0.14

9.47 ± 0.13

0.300 ± 0.097

29

1.04 ± 0.12

10.01 ± 0.18

0.103 ± 0.030

30

1.22 ± 0.14

9.77 ± 0.14

0.159 ± 0.047

  1. Values are expressed as the mean ± SEM of at least three independent measurements
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Journal of Biomedical Science

ISSN: 1423-0127