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Table 2 Schild analysis and Ke values of antagonism of test compounds against fentanyl to MORs by cAMP functional assay

From: Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent

Cmpd Slope ± SEM pA2 ± SEM Ke (nM) ± SEM
4b 1.12 ± 0.14 9.47 ± 0.13 0.300 ± 0.097
29 1.04 ± 0.12 10.01 ± 0.18 0.103 ± 0.030
30 1.22 ± 0.14 9.77 ± 0.14 0.159 ± 0.047
  1. Values are expressed as the mean ± SEM of at least three independent measurements