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Table 5 Descriptive pharmacokinetic parameters of 29 exposure

From: Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent

Dosing route/dose AUC (nM-h) Tmax (h) Apparent half-life, t½ (h)
IV, 2 mg/kg 207 0.08 0.58
PO, 5 mg/kg 64 0.1 0.99
IP, 2 mg/kg
Plasma
397 0.12 0.94
IP, 2 mg/kg Brain 634 0.32 1.34