Table 5 Descriptive pharmacokinetic parameters of 29 exposure
From: Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent
Dosing route/dose | AUC (nM-h) | Tmax (h) | Apparent half-life, t½ (h) |
|---|---|---|---|
IV, 2Â mg/kg | 207 | 0.08 | 0.58 |
PO, 5Â mg/kg | 64 | 0.1 | 0.99 |
IP, 2Â mg/kg Plasma | 397 | 0.12 | 0.94 |
IP, 2 mg/kg Brain | 634 | 0.32 | 1.34 |