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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Influenza a virus NS1 resembles a TRAF3-interacting motif to target the RNA sensing-TRAF3-type I IFN axis and impair antiviral innate immunity

Fig. 7

Model for IAV NS1-mediated immune evasion through targeting TRAF3 to impair the RIG-I, TLR3, and TLR7 pathways to type I IFN production. RIG-I, TLR3, and TLR7 are involved in detecting IAV RNA to trigger type I IFN-mediated antiviral immunity. IAV NS1 interacted with TRAF3 through its TRAF3-binding motif (TIM) in the C-terminal effector domain. This interaction blocked TRAF3 ubiquitination and activation, which is required for RIG-I, TLR3, and TLR7 pathways to type I IFN production

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Journal of Biomedical Science

ISSN: 1423-0127