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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: Restoration of 5-methoxytryptophan protects against atherosclerotic chondrogenesis and calcification in ApoE−/− mice fed high fat diet

Fig. 3

5-MTP decreases HFD-induced SOX9 expression in aortic atherosclerotic lesions. SOX9 and osterix contents in aorta tissues from ApoE−/− mice fed chow diet with saline (n = 3) or HFD with saline (n = 6) or L-5-MTP (n = 5) twice weekly for 20 wk were analyzed by immunohistochemistry. Negative control represents staining with a 2nd antibody. Representative microphotographs of the immunohistochemical staining for A SOX9 and C osterix are shown. Immunopositive areas of B SOX9 and D osterix in aorta tissues were quantified as a percentage of the total aortic area in each section. Data represent mean ± SEM. Lu lumen, Neo neo-intima, Med media, An adventitia. P < 0.05, P < 0.01 determined by a one-way ANOVA

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Journal of Biomedical Science

ISSN: 1423-0127