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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: CRISPR and KRAS: a match yet to be made

Fig. 3

Schematic representation of CRC development upon occurrence of mutations. APC inactivation is responsible for the initial differentiation of the normal epithelial tissue into a dysplastic crypt. Further, mutations in KRAS lead to the formation of an adenomatous lesion, which could be followed by abnormalities in CIN, DCC, DPC4 and P53 that result in cancerous tissue in the colon. (Fig. 3 is adapted from Fearon et al., 2011 [79, 175]) (Figure generated using SMART Servier Medical Art tools—https://smart.servier.com/.)

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