Fig. 6

ROR2 has a protective role in primary melanoma. ROR2 expression in the Leeds Melanoma Cohort (n = 703) correlates negatively with the AJCC T-stage (A) and mitotic rate (B). C ROR2 expression negatively correlates with Breslow thickness. Violin plot of ROR2 mRNA levels in dataset GSE57715. ROR2 levels were compared in patients with Breslow depth lower than 2 mm (n = 135), between 2 and 4 mm (n = 59), and greater than 4 mm (n = 50). Statistical significance was tested by ANOVA. D ROR2 expression negatively correlates with ulceration in the LMC. E High ROR2 expression correlates with longer melanoma specific survival (MSS). Kaplan–Meier MSS analysis of 703 primary melanomas stratified by ROR2 median split. F ROR2 mRNA expression is higher in LMC class 1 with the best melanoma specific survival. The LMC classes with the best (class 1) and worst (class 3) survival were compared for ROR2 mRNA levels [37]. Mann–Whitney test for group comparisons and Cox proportional hazards regression for survival analysis. n.s.: no significant, *: p < 0.01, **: p < 0.001, ***: p < 0.0001