Skip to main content

Table 1 Half-maximal inhibitory concentrations (IC50) values for single RBD-chAbs against pseudoviruses of SARS-CoV-2 variants

From: Antibody cocktail effective against variants of SARS-CoV-2

 

SARS-CoV-2 pseudovirus IC50 (ng/ml)

 

D614G

B.1.1.7

(UK, Alpha)

B.1.351

(SA, Beta)

P1

(Brazil, Gamma)

RBD-chAb-1

24.35 ± 5.55

33.46 ± 17.9

46.71 ± 10.98

17.09 ± 7.72

RBD-chAb-15

21.25 ± 11.13

39.73 ± 16.66

30.13 ± 12.03

7.18 ± 5.46

RBD-chAb-25

9.92 ± 2.04

Non-N

Non-N

Non-N

RBD-chAb-28

9.55 ± 4.16

11.29 ± 5.93

16.52 ± 6.03

4.18 ± 1.80

RBD-chAb-45

1.58 ± 0.54

2.06 ± 0.58

2.68 ± 0.84

0.76 ± 0.14

RBD-chAb-51

1.30 ± 0.27

3.07 ± 0.72

1.26 ± 0.58

0.70 ± 0.19

 

SARS-CoV-2 pseudovirus IC50 (ng/ml)

 

B.1.429

(California, Epsilon)

B.1.526

(NY, Iota)

B.1.617.1

(India, Kappa)

B.1.617.2

(India, Delta)

RBD-chAb-1

21.6 ± 11.13

428.2 ± 166.3

117.7 ± 55.64

429.3 ± 36.55

RBD-chAb-15

11.72 ± 5.40

87.89 ± 5.09

67.71 ± 15.84

103.6 ± 16.57

RBD-chAb-25

6.51 ± 0.73

91.95 ± 66.85

42.27 ± 7.27

35.5 ± 12.14

RBD-chAb-28

3.28 ± 1.71

44.07 ± 29.58

60.62 ± 37.4

94.13 ± 22.07

RBD-chAb-45

0.91 ± 0.16

4.23 ± 1.51

5.95 ± 0.72

15.51 ± 4.58

RBD-chAb-51

1.32 ± 0.75

2.28 ± 0.08

4.55 ± 1.2

8.04 ± 2.11

  1. Data are from three independent experiments and are shown as mean ± SEM
  2. Non-N non-neutralizing
Back to article page

Journal of Biomedical Science

ISSN: 1423-0127