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Table 2 Half-maximal inhibitory concentrations (IC50) values for RBD-chAb combinations against pseudoviruses of SARS-CoV-2 variants

From: Antibody cocktail effective against variants of SARS-CoV-2

 

SARS-CoV-2 pseudovirus IC50 (ng/ml)

 

D614G

B.1.1.7

(UK, Alpha)

B.1.351

(SA, Beta)

P1

(Brazil, Gamma)

RBD-chAb-15 + 45

7.41 ± 2.22

7.28 ± 1.40

4.27 ± 0.95

5.27 ± 2.82

RBD-chAb-28 + 45

10.69 ± 1.83

11.77 ± 0.80

8.25 ± 1.43

5.40 ± 0.72

RBD-chAb-15 + 51

4.76 ± 0.48

4.66 ± 1.25

3.55 ± 0.78

3.35 ± 0.55

RBD-chAb-28 + 51

10.06 ± 2.71

12.72 ± 2.81

8.73 ± 2.84

4.19 ± 0.92

 

SARS-CoV-2 pseudo virus IC50 (ng/ml)

 

B.1.429

(California, Epsilon)

B.1.526

(NY, Iota)

B.1.617.1

(India, Kappa)

B.1.617.2

(India, Delta)

RBD-chAb-15 + 45

6.31 ± 2.33

21.7 ± 5.36

19.35 ± 7.08

25.69 ± 8.73

RBD-chAb-28 + 45

11.04 ± 0.90

6.81 ± 0.49

27.06 ± 1.81

21.55 ± 2.32

RBD-chAb-15 + 51

5.86 ± 0.87

8.34 ± 0.2

20.29 ± 0.86

10.13 ± 1.25

RBD-chAb-28 + 51

12.15 ± 2.67

11.44 ± 2.85

18.61 ± 4.24

14.22 ± 6.98

  1. Data are from at least two independent experiments and are shown as mean ± SEM
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Journal of Biomedical Science

ISSN: 1423-0127