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Table 3 List of identified variants within katG gene using long-read sequencing approach in susceptible or INH-resistance MTB isolates

From: Integrative utility of long read sequencing-based whole genome analysis and phenotypic assay on differentiating isoniazid-resistant signature of Mycobacterium tuberculosis

 

Variants in katG

Isolate no.

Variant no.

Susceptible only

Leu101Arg/Ile462Asn/Ala478Val/Pro566Thr/Leu631Pro

10

5

Susceptible and Resistant

Gln50Lys/Asn51Thr/Glu81Gln/Met84Thr/Pro92Ala/Gly123Arg/Lys158Asn/Tyr304Asp/Gly307Glu/Asp311Asn/Pro325Arg/Lys327Asn/Lys356Met/Tyr390Asp/Glu399Lys/Pro443His/Arg463Leu/Leu546Pro/Thr564Pro/Leu611Pro/Val659Leu

52

21

 

Variants (identified copy) in katG

Isolate no.

Variant no.

Low INH resistant isolate

Gly14Arg(2)/ Gly124Ala(2)/ Leu141Phe(2)/ Leu141Met(2)/ Val68Ala(2)/ Pro235Gln(2)

Ser374Phe(2)/ Asp509Gly(3)/ Gly570Ala(2)/ Gly665Val(2)/ Leu704Val(2)/ Phe737Leu(2)

20

12

High INH resistant isolate

Tyr95Phe(2)/ Pro136Ala(2)/ Ser160Ala(2)/ Val188Leu(5)/ Glu287Asp(2)/ Ser315Thr(13)/ Ser315Gly(1)/ Ser315Asn(1)/ Thr354Ile(2)/ Ser376Met(3)/Gly560Val(2)/Thr579Asn(2)/Lys600Glu/Arg(2)/ Asn602Lys/Asp(3)/ Met664Leu/Ile(2)

22

15

  1. The value highlighted in underline text presents the number of isolate harboring the amino acid substitution that has been identified in other study