Table 5 The relevance between the identified variant within the katG gene and the results of DST or MIC testing
Genotyping no. | High confidence variant | Novel variant | MIC of INH (mg/mL) | DST of INH (mg/mL) | Frequency (%) |
|---|---|---|---|---|---|
1 | Ser315Thr | N/A | 2 | 1 | 25% (5/20) |
2 | Ser315Thr | Thr376Met Pro136Ala | 2 | 1 | 10% (2/20) |
3 | Ser315Thr | Val188Leu Ser160Ala | 2 | 1 | 15% (3/20) |
4 | Ser315Thr | Val188Leu Thr579Asn | 4 | 1 | 10% (2/20) |
5 | Ser315Thr | Thr579Asn | > 4 | 1 | 5% (1/20) |
6 | Ser315Thr | Lys600Glu | > 4 | 1 | 10% (2/20) |
7 | N/A | Glu287Asp Lys310Thr Thr579Asn | > 4 | 1 | 10% (2/20) |
8 | N/A | Glu318Gln Ile552Arg Gly599Arg | 0.5 | > 0.2 | 5% (1/20) |
9 | N/A | Glu287Asp Thr376Met Lys600Arg Ser315Asn | 0.03 | > 0.2 | 5% (1/20) |
10 | N/A | Met664Ile Ser315Gly | 0.06 | > 0.2 | 5% (1/20) |