Table 6 Top 20 identified global SARS-CoV-2 spike protein mutations
From: Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection
Mutant amino acid position | Domain of S protein | Number of sequences detected | Percentage in total cases (%) | Latest month increased (2021/10/22-11/22) |
|---|---|---|---|---|
D614G | S1 CTD | 4,389,691 | 96.47 | 5.0 |
L452R | RBM | 2,370,119 | 52.09 | 9.6 |
P681R | S1 CTD | 2,330,791 | 51.22 | 9.9 |
T478K | RBM | 2,315,734 | 50.89 | 9.9 |
T19R | S1 NTD | 2,311,542 | 50.80 | 9.9 |
D950N | S2 | 2,230,596 | 49.02 | 10.1 |
EFR156G | S1 NTD | 2,178,419 | 47.87 | 10.3 |
G142D | S1 NTD | 1,443,479 | 31.72 | 13.7 |
N501Y | RBM | 1,103,940 | 24.26 | 0.0 |
P681H | S1 CTD | 1,038,019 | 22.81 | 0.0 |
HV69- | S1 NTD | 980,548 | 21.55 | 0.0 |
T716I | S2 | 978,901 | 21.51 | 0.0 |
A570D | S1 CTD | 972,330 | 21.37 | 0.0 |
S982A | S2 | 971,209 | 21.34 | 0.0 |
T95I | S1 NTD | 970,839 | 21.33 | 0.0 |
D1118H | S2 | 970,596 | 21.33 | 1.0 |
Y144- | S1 NTD | 960,965 | 21.12 | 13.3 |
A222V | S1 NTD | 395,936 | 8.70 | 6.5 |
E484K | RBM | 192,337 | 4.23 | 0.0 |
L18F | S1 NTD | 190,391 | 4.18 | 0.5 |