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Table 3 Human gene sets significantly downregulated by DBPR114

From: Novel FLT3/AURK multikinase inhibitor is efficacious against sorafenib-refractory and sorafenib-resistant hepatocellular carcinoma

Gene set

Size

p value

FDR

Description

Reference

HALLMARK_G2M_CHEKPOINT

190

0.000

0.000

Genes involved in the G2/M checkpoint that progress through the cell division cycle

MSigDB v5.0

HALLMARK_MITOTIC_SPINDLE

197

0.001

0.001

Genes essential for mitotic spindle assembly

MSigDB v5.0

HALLMARK_E2F_TARGETS

195

0.003

0.002

Genes encoding cell cycle–related targets of E2F transcription factors

MSigDB v5.0

HALLMARK_MTORC_SIGNALING

195

0.001

0.005

Genes upregulated through activation of mTOR complex 1

MSigDB v5.0

  1. Gene set enrichment analysis was performed on Huh7 xenograft tumors (FDR < 0.05). The Huh7 tumors from the vehicle control and treated groups were harvested at the end of studies (Fig. 4). The tumor RNA was isolated and analyzed for human gene expressions through mRNA sequencing