Fig. 1
From: SLCO4A1-AS1 promotes colorectal tumourigenesis by regulating Cdk2/c-Myc signalling
SLCO4A1-AS1 is upregulated in CRC and predicts poor prognosis. a Heatmap of the 30 top upregulated lncRNAs from TCGA CRC dataset identified by unsupervised hierarchical clustering. b and c SLCO4A1-AS1 is overexpressed in multiple cancer types (b) and shows high abundance in CRC based on TCGA database (c). d Validation of SLCO4A1-AS1 overexpression in CRC samples from four independent GEO databases. e SLCO4A1-AS1 was upregulated (> two fold) in 57% (62 of 109) of CRC tissues compared with their paired NCTs in CRC cohort 1. Relative expression levels of SLCO4A1-AS1 were quantified by qRT-PCR. f Kaplan–Meier survival analysis according to SLCO4A1-AS1 levels in the CRC dataset of TCGA. Overall survival (g) and disease-free survival (h) analyses according to SLCO4A1-AS1 levels were analyzed using the Kaplan–Meier method. i SLCO4A1-AS1-based and TNM-based prediction models were constructed using a ROC method. j The associations between different clinical characteristics and SLCO4A1-AS1 expression. Statistical significance was performed using the χ2 test. k Cox univariate and multivariate regression analyses were performed in CRC cohort 1. *P < 0.05; **P < 0.01