Fig. 2

LRG1 protein structure. Schematic representation of LRG1 protein structure. A LRG1 is a 312 aa protein which contains 8 leucine-rich repeats (LRR), 4 N-linked, 1 O-linked glycosylation sites and 2 disulphide bonds. Upon cleavage of the N-terminal signal peptide, LRG1 is released in the extracellular space. The mature form, around 50 kDa, may vary in weight depending on the glycosylation pattern and multimer formation. B LRG1 structure as predicted by ALPHAFOLD2 through deep learning algorithms [223]. β-sheet in green, α-helix in red