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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Early innate immune response triggered by the human respiratory syncytial virus and its regulation by ubiquitination/deubiquitination processes

Fig. 1

Main pathways activated in early innate anti-viral immunity after HRSV infection. The signaling pathways begin with the recognition of HRSV RNA by RIG-I and TLR3 receptors. The signal is transduced through adaptor proteins (MAVS, TRIF) to TRAF proteins (TRAF3/6), which activate the kinase complexes (NEMO, TBK1, IKKα/β/ε, TAB1, and TAK1), triggering the activation of transcription factors IRF3/7, NF-κB and AP1 to express type I/III IFN, cytokines, and anti-viral genes. The released IFNs binds to their receptors (IFNAR1/IFNAR2) in an autocrine and paracrine manner to induce JAK/STAT-mediated expression of multiple ISGs

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Journal of Biomedical Science

ISSN: 1423-0127