Fig. 3

HRSV NS1 and NS2 inhibition of RIG-I ubiquitination. HRSV NS1 and NS2 proteins disrupt the innate immune cascade in infected cells by interfering with the K63 ubiquitination of RIG-I. This process involves NS1 binding to the PRY-SPRY motif of TRIM25 (A) or NS2 binding to RIG-I CARDs (B). A “U” inside a green circle depicts ubiquitin residues