Fig. 4From: Early innate immune response triggered by the human respiratory syncytial virus and its regulation by ubiquitination/deubiquitination processesHRSV NS1-mediated STAT2 ubiquitination and degradation. NS1, and maybe NS2, form an E3 ligase complex with elongin C and cullin 2 that ubiquitinates STAT2 through K48 linkages. This modification labels STAT2 for proteasomal degradation, thus inhibiting IFN signaling. A “U” inside a green circle depicts ubiquitin residuesBack to article page