Early innate immune response triggered by the human respiratory syncytial virus and its regulation by ubiquitination/deubiquitination processes

Martín-Vicente, María; Resino, Salvador; Martínez, Isidoro

doi:10.1186/s12929-022-00793-3

Journal of Biomedical Science

Table 1 Ubiquitinases (E3 ligases) and deubiquitinases (proteases) that regulate intracellular signaling

From: Early innate immune response triggered by the human respiratory syncytial virus and its regulation by ubiquitination/deubiquitination processes

Target protein	Enzyme (symbol)	Name	Activity	Ubiquitin linkage	Refs.
RIG-I	TRIM25	Tripartite Motif-containing protein 25	E3 ligase	K63	[44]
	RNF135	RING Finger Protein 135	E3 ligase	K63	[122]
	TRIM4	Tripartite Motif-containing protein 4	E3 ligase	K63	[181]
	MEX3C	Mex-3 RNA binding family member C	E3 ligase	K63	[84]
	USP4	Ubiquitin Specific Protease 4	Protease	K48	[172]
	RNF122	RING Finger Protein 122	E3 ligase	K48	[174]
	RNF125	RING Finger Protein 125	E3 ligase	K48	[5]
	CBL (c-Cbl)	Casitas B lineage lymphoma	E3 ligase	K48	[19]
	TRIM40	Tripartite Motif-containing protein 40	E3 ligase	K27 and K48	[193]
	CYLD	Cylindromatosis	Protease	K63	[42]
	USP21	Ubiquitin Specific Protease 21	Protease	K63	[37]
MAVS	TRIM31	Tripartite Motif-containing protein 31	E3 ligase	K63	[93]
	TRIM21	Tripartite Motif-containing protein 21	E3 ligase	K27	[180]
	RNF125	RING Finger Protein 125	E3 ligase	K48	[5]
	SMURF1/2	SMAD Specific E3 ubiquitin-protein ligase 1/2	E3 ligase	K48	[126, 176]
	ITCH	Itchy E3 ubiquitin-protein ligase	E3 ligase	K48	[22, 187]
	RNF5	RING Finger Protein 5	E3 ligase	K48	[199]
	MARCH5	Membrane-associated RING-CH 5	E3 ligase	K48	[186]
	TRIM25	Tripartite Motif-containing protein 25	E3 ligase	K48	[16]
	MARCH8	Membrane-associated RING-CH 8	E3 ligase	K27	[77]
	TRIM29	Tripartite Motif-containing protein 29	E3 ligase	K11	[178]
	YOD1 (OTUD2)	Ovarian Tumor Deubiquitinase2	Protease	K63	[94]
TRAF3	RNF166	RING Finger Protein 166	E3 ligase	K63	[18]
	HECTD3	HECT Domain E3 Ubiquitin Protein Ligase 3	E3 ligase	K63	[86]
	RNF216 (Triad3A)	RING Finger Protein 216	E3 ligase	K48	[120]
	OTUB1/2	OTU Deubiquitinase, Ubiquitin Aldehyde Binding 1 and 2	Protease	K63	[88]
	ZC3H12A (MCPIP1)	Monocyte Chemotactic Protein-Induced Protein-1	Protease	K63	[20, 91]
TRAF6	TRAF6	TNF Receptor Associated Factor 6	E3 ligase	K63	[85]
	RNF166	RING Finger Protein 166	E3 ligase	K63	[18]
	ZC3H12A (MCPIP1)	Monocyte Chemotactic Protein-Induced Protein-1	Protease	K63	[91]
	OTUB1/2	OTU Deubiquitinase, Ubiquitin Aldehyde Binding 1 and 2	Protease	K63	[88]
	TNFAIP3 (A20)	TNFα Induced Protein 3	Protease	K63	[3, 130, 149]
	TRIM38	Tripartite Motif-containing protein 38	E3 ligase	K48	[195]
TBK1	MIB1/2	MIB E3 ubiquitin-protein ligase	E3 ligase	K63	[87]
	RNF41 (Nrdp1)	RING Finger Protein 41	E3 ligase	K63	[170]
	RNF128	RING Finger Protein 128	E3 ligase	K63	[152]
	DTX4	Deltex E3 Ubiquitin Ligase 4	E3 ligase	K48	[26]
	TRAIP (TRIP)	TRAF Interacting Protein	E3 ligase	K48	[191]
	TRIM27	Tripartite Motif-containing protein 27	E3 ligase	K48	[198]
NEMO	TRAF6	TNF Receptor Associated Factor 6	E3 ligase	K63	[31]
	TRIM23	Tripartite Motif-containing protein 23	E3 ligase	K27	[4]
	LUBAC	Linear Ubiquitin chain Assembly Complex	E3 ligase	M1	[169]
	TRAF7	TNF Receptor Associated Factor 7	E3 ligase	K29	[201]
	TRIM29	Tripartite Motif-containing protein 29	E3 ligase	K48	[177]
TAK1	TRAF6	TNF Receptor Associated Factor 6	E3 ligase	K63	[171]
	CYLD	Cylindromatosis	Protease	K63	[1]
	ITCH	Itchy E3 ubiquitin-protein ligase	Protease	K63	[1]
TBK1-IKK complex	TNFAIP3 (A20)	TNFα Induced Protein 3	Protease	K63	[46, 127, 144]
IRF3	TRIM26	Tripartite Motif-containing protein 26	E3 ligase	K48	[173]
	TRIM21	Tripartite Motif-containing protein 21	E3 ligase	K48	[66]
	RBCK1 (RNF54)	RING Finger Protein 54	E3 ligase	K48	[190]
	CBL (c-Cbl)	Casitas B lineage lymphoma	E3 ligase	K48	[196]
	UBE3C (RAUL)	Ubiquitin Protein Ligase E3C	E3 ligase	K48	[188]
IRF7	UBE3C (RAUL)	Ubiquitin Protein Ligase E3C	E3 ligase	K48	[188]
IRF7	TRIM21	Tripartite Motif-containing protein 21	E3 ligase	K48	[65]
NF-κB	MKRN2	Makorin Ring Finger Protein 2	E3 ligase	K48	[151]
	PDLIM1	PDZ And LIM Domain 1	E3 ligase	K48	[163]
	COMMD1/Cul2	Copper Metabolism Domain Containing 1/Cullin 2	E3 ligase	K48	[48]
	TRAF7	TNF Receptor Associated Factor 7	E3 ligase	K29	[201]
STAT1	RNF31	RING Finger Protein 31	E3 ligase	M1	[202]
STAT1	OTULIN	OTU deubiquitinase with Linear linkage specificity	Protease	M1	[202]

Ubiquitination/deubiquitination processes regulate many proteins involved in RIG-I and TLR3 signaling pathways. Different E3 ligases (add ubiquitin chains to the target protein) or proteases (remove the ubiquitin chains from the target protein) modify the activity, localization, or stability of the target proteins. E3 ligases add ubiquitin residues to the target proteins; proteases (deubiquitinases) remove ubiquitin residues from the target proteins

Back to article page

ISSN: 1423-0127

Contact us

Submission enquiries: Access here and click Contact Us
General enquiries: info@biomedcentral.com