Fig. 3
From: O-GlcNAc transferase couples MRE11 to transcriptionally active chromatin to suppress DNA damage
MRE11 and O-GlcNAc marked genes resist CDK9 inhibitor effect on mRNA levels. A Venn-diagram showing the overlap between O-GlcNAc (GSE121474) and MRE11 (GSE63202) ChIP-seq peaks from LNCaP cells. B KEGG pathway enrichment analysis of the indicated gene-sets as reported in A. C Effects of CDK9 and CDK9 + OGT inhibition on expression levels of genes bound by MRE11 and/or O-GlcNAc, or neither. Significantly (p < 0.01) affected mRNAs after four hours treatment of LNCaP cells were identified from GSE116778. D C4-2 cells were treated with 20 nM NVP2, 10 µM Mirin and combination of both compounds for 8 h. The effects on RNA Pol II phosphorylation was assessed by western blot. Data is representative of four biological replicates