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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: O-GlcNAc transferase couples MRE11 to transcriptionally active chromatin to suppress DNA damage

Fig. 4

CDK9 inhibition induces DNA damage in prostate cancer cells. A C4-2 cell line was treated with 20 nM NVP2 or 20 nM NVP2 + 20 µM OSMI-4 for four hours, fractions isolated and samples analyzed using western blot. B Inhibition of CDK9 using NVP2 induces DNA damage in prostate cancer cells as measured using phosphorylation of H2AX. C, D Cells were treated for 24 h and analyzed using western blot

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