Fig. 7
From: A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis
Schematic diagram illustrates the molecular mechanism how STIL contributes to tumor development via the FOXM1-mediated transcriptional activation of target genes under hypoxia. HIF1α becomes stable under hypoxia in cancer, and translocates to the nucleus to upregulate STIL expression. Furthermore, HIF1α was reported to drive FOXM1 expression [10, 11]. Thus, STIL can associate with FOXM1 to modulate the expression of downstream target genes involved in the EMT process and stemness, and consequently promotes tumor development, metastasis, and poor prognosis