Skip to main content
Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Cysteine-rich protein 2 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in mice

Fig. 1

CRP2 deficiency protects against AAA formation. A Apoe−/− mice were subjected to saline or Ang II infusion and abdominal aortas harvested at 1, 2, and 4 weeks for immunohistochemistry to detect CRP2 expression (brown). B Apoe−/− and Csrp2−/−Apoe−/− mice were infused with saline (Apoe−/− n = 12, Csrp2−/−Apoe−/− n = 13) or Ang II (Apoe−/− n = 17, Csrp2−/−Apoe−/− n = 16) mice were infused with saline for 4 weeks and representative aortas are shown. C Ang II infusion for 4 weeks induced AAA in 88% of Apoe−/− mice (n = 17) while only 37.5% in Csrp2−/−Apoe−/− mice developed AAA (n = 16). *P < 0.05 (Fisher’s exact test) compared with Ang II-infused Apoe−/− group. D The ratio of SRA/IRA 4 weeks after saline or Ang II infusion in Apoe−/− and Csrp2−/−Apoe−/− mice. *P < 0.05 compared with the corresponding Ang II-infused Apoe−/− group. E H&E staining and SM α-actin (brown) immunohistochemistry were performed on aneurysmal segments from Apoe−/− and Csrp2−/−Apoe−/− mice infused with Ang II for 4 weeks. Higher magnification of the boxed area is shown at the respective right panel. T, thrombus

Back to article page