Skip to main content
Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Cysteine-rich protein 2 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in mice

Fig. 4

Loss of CRP2 attenuates Ang II-increased blood pressure and collagen deposition in aneurysmal mouse aorta. A Apoe−/− (n = 13) and Csrp2−/−Apoe−/− (n = 8) mice were infused with Ang II and SBP (mmHg) measured at baseline and at different days (7, 14, 21, and 28 d). §P < 0.05 compared with the respective baseline at d 0; *P < 0.05 compared with the corresponding Apoe−/− group. B Mice were infused with saline or Ang II for 10 d and abdominal aortas harvested for measurement of tensile strength using TA-ElectroForce® 3200 Series III system. §P < 0.05 compared with saline group; *P < 0.05 compared with the corresponding Apoe−/− group. C Quantitative analysis of the ultimate tensile strength of abdominal aortas from Apoe−/− and Csrp2−/−Apoe−/− (saline n = 3 each group, Ang II n = 6 each group). *P < 0.05. D, E Mice were infused with saline or Ang II and abdominal aortas harvested at different time points for histological analysis. Masson’s trichrome staining for collagen (blue) of aneurysmal segments from saline and Ang II-infused Apoe−/− D and Csrp2−/−Apoe−/− E mice at 1, 2, and 4 weeks. D, E Lower panels, higher magnification of the boxed areas in the respective upper panels. F, G Quantitative analysis of collagen-positive area of aneurysmal sections 2 weeks (F) and 4 weeks (G) after saline or Ang II infusion. Saline, n = 6 each group; Ang II, n = 8 each group. §P < 0.05 compared with the respective saline group; *P < 0.05 compared with the corresponding Apoe−/− group

Back to article page