Fig. 4

Antagonism of type I interferon by SARS CoV-2 proteins. Interferon responses are triggered by SARS-CoV-2 RNA. The nonstructural protein of SARS-CoV-2 target different proteins and inhibit their anti-inflammatory interferon response. Potential proteins and targets needed to be further studied are shown in brown question marks. MDA5, melanoma differentiation-associated protein 5; TOM70, translocases of outer membrane 70; TBK1, TANK binding kinase 1; IKKɛ, inhibitor of k-B kinase-ɛ; IFN, interferon; IRF, interferon regulatory factor; IFNAR, interferon-α/β receptor; STAT, signal transducer and activator of transcription; Nsp, nonstructural protein; ORF, open reading frames. (Created with BioRender.com.)