Fig. 9

Smurf2 expression is restored in the glomeruli of db/db mice treated with the ki16425. Eight-week-old wild-type and db/db mice were intraperitoneally injected with the vehicle or ki16425 (10 mg/kg/day) for 8 weeks and the mice were sacrificed. Immunohistochemical detection of Smurf2 was performed in the kidney tissues using DAB. The nuclei were counterstained with hematoxylin. The representative images are depicted (original magnification, 200 ×; scale bars, 20 μm; n = 3)