Fig. 4

Molecular docking analysis of heteronemin on integrin αvβ3. A Heteronemin docking pose for mode 1 (white) in the RGD pocket is shown as a stick model. B The mode 2 of heteronemin (yellow) inside the RGD pocket of integrin αvβ3. C Protein–ligand interactions for heteronemin binding mode 1 (white stick) are analyzed to find hydrogen bonds displayed as red dashed lines. D Hydrogen bonds are displayed as red dashed lines in the heteronemin binding mode 2 (yellow stick)