Fig. 7
The best binding mode of heteronemin is superimposed with estradiol. Thyroxine (T4), resveratrol (RSV), estradiol (E2), and heteronemin bind into integrin αvβ3, and were performed in red, blue, orange, and white, respectively. A T4 (red), RSV (blue) and E2 (orange) binding mode represent the thyroid hormone pocket, resveratrol pocket, and steroid pocket, respectively. B The best-docked mode of heteronemin maps with the E2. C Heteronemin prefers to occupy the binding sites in a part of the steroid pocket